Stibanate (Sodium Antimony Gluconate) with Pedunculine in the Treatment of Kala-Azar
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چکیده
منابع مشابه
The Treatment of Kala-Azar with Sodium Antimony-V-Gluconate: Preliminary Observations *The work reported in this paper was undertaken under the Endowment Fund of the Calcutta School of Tropical Medicine, aided by a grant from the Indian Research Fund Association.
A pentavalent antimony compound (Sdt. 561, solustibosan, antimony-v-hexonate, containing 20 mg. of antimony per c.cm. of solution) , that made a stable solution and could be given intramuscularly, was first introduced b) Prof. H. Schmidt, the pioneer worker on pent*1' valent antimony compounds. Kikuth and Schmidt (1938) found that this compound possessed a marked curative action in the le*,' ma...
متن کاملThe Treatment of Kala-Azar with Sodium Antimony Gluconate (Stibatin). Further Observations on the Treatment of Thirty-Two Cases
couraging results, it was decided to a further extensive trial with this drug in certain hyperendemic kala-azar areas in the tea districts of Mangaldai, as an anti-kala-azar drug of such promising quality was indispensable, especially when, due to present war-time conditions, other pentavalent antimony compounds of proved value, e.g. solustibosan, neostibosan, etc., suitable for mass administra...
متن کاملStudies on stibanate resistant Leishmania donovani isolates of Indian origin.
Studies with 26 clones of L. donovani promastigotes derived from three different Indian isolates indicated that wild type parasites are mixture of stibanate sensitive and resistant cells. Both forms of the parasite were resistant to the drug. Infection with resistant parasites appears to be the primary reason of high rate of pentavalent antimony unresponsiveness among Indian kala-azar patients....
متن کاملA Preliminary Note on the Treatment of 21 Cases of Kala-Azar with Sodium Antimony Gluconate. (With Special Reference to Its Suitability for Mass Administration on Tea Estates)
Introduction.?The senior writer, Burke (1943), made an appeal for an efficient successor to neostibosan (Bayer), this, preferably, to be a British product. What seems to be an almost perfect answer to that appeal?and indeed a British product?is the preparation stibatin (Glaxo Laboratories), or sodium antimony gluconate (antimony v-hexonate), a crystal-clear sterile solution containing 20 mg. of...
متن کاملPharmacovigilance in kala-azar patients with severe thrombocytopenia caused by sodium antimony gluconate & miltefosine.
Sodium antimony gluconate (SAG) and miltefosine used in the treatment of kala-azar are known to cause several side effects but severe thrombocytopenia has not been reported. Four cases of severe thrombocytopenia, two caused by SAG and two by miltefosine were promptly detected and treated by immediate withdrawal of the offending drugs, platelet and blood transfusions and dexamethasone. After imp...
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عنوان ژورنال:
دوره 82 شماره
صفحات -
تاریخ انتشار 1947